TentaGel® resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted. The PEG spacer is attached to the matrix via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. As PEG is a "chameleon type" polymer with hydrophobic and hydrophilic properties, the graft copolymer shows modified physico chemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix). These graft copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of MW 3000 Da.

TentaGel® R represents a special designed resin for research synthesis. Long peptide sequences (up to 100 residues) and difficult sequences are synthesized on this support. The resin shows an increased swelling volume and a significant lower loading.

This resin is functionalized with a modified Rink Amide linker and is ideal for the Fmoc SPPS of peptide amides. Cleavage from this support is achieved by 95% TFA.

L 4, L 5, L 6, L 7, L 24, L 25; ee also: General Information