Polystyrene Sieber Resin

Product information

This resin contains the Sieber amide (Xanthenyl) linker attached to Polystyrene via a methl ether bond. It is ideal for the synthesis of partially protected peptide amides. Cleavage with only 1 % TFA in DCM - this super acid sensitive resin is well suited to generate protected peptide amide fragments. As the Sieber linker is less steric hindered compared to the Rink handle, bulky building blocks can be attached to the resin more easily and with higher yields.


L 64 Sieber Amide Resins

  1. Sieber, P. A New Acid-Labile Anchor Group for the Solid-Phase Synthesis of C-Terminal Peptide Amides by the Fmoc Method. Tetrahedron Lett. 1987, 28 (19), 2107-2110. doi: 10.1016/s0040-4039(00)96055-6.
  2. Somlai, C.; et al. Design and synthesis of 3,9-substituted xanthene derivatives: Application for solid-phase synthesis in Peptides 1992: Proceedings of the Twenty-Second European Peptide Symposium, 1992, Interlaken, Switzerland; Schneider, C. H., Eberle, A. N., Eds.; ESCOM Science: Dordrecht, Netherlands, 1993, 198.