Polystyrene Weinreb AM Resin

Product information

This resin contains the Weinreb amide (N-Methoxy-ß-alanine) linker attached to aminomethylated polystyrene. This support is suited for the synthesis of peptide aldehydes or ketones. Cleavage is accomplished by treatment with LiAlH4 or Grignard reagents, respectively.


L 65 Weinreb AM Resins

  1. Fehrentz, J.-A.; Paris, M.; Heitz, A.; Velek, J.; Liu, C.-F.; Winternitz, F.; Martinez, J. Improved Solid Phase Synthesis of C-Terminal Peptide Aldehydes. Tetrahedron Lett. 1995, 36 (43), 7871-7874. doi: 10.1016/0040-4039(95)01646-y.
  2. Dinh, T. Q.; Armstrong, R. W. Synthesis of Ketones and Aldehydes via Reactions of Weinreb-Type Amides on Solid Support. Tetrahedron Lett. 1996, 37 (8), 1161-1164. doi: 10.1016/0040-4039(95)02400-x.
  3. Tice, C. M.; Michelotti, E. L.; Mata, E. G.; Nicolàs, E.; Garcia, J.; Albericio, F. Solid Phase Synthesis of α-Acylamino-α,α-Disubstituted Ketones. Tetrahedron Lett. 2002, 43 (42), 7491-7494. doi: 10.1016/s0040-4039(02)01803-8.