Polystyrene AM Ramage

Product information

In this resin Ramage's dibenzocycloheptadiene linker is attached to aminomethylated polystyrene. After Fmoc removal the resin can be acylated and used in Fmoc SPPS. The linker is essentially more acid sensitive than the Rink amide or PAL linker. Therefore, peptide amides can be cleaved with 3% TFA in DCM and thus it's possible to release acid sensitive peptides or protected peptide fragments.


L 63 Polystyrene AM Ramage Resins

  1. Ramage, R.; Irving, S. L.; McInnes, C. Design of a Versatile Linker for Solid Phase Peptide Synthesis: Synthesis of C-Terminal Primary/Seconary Amides and Hydrazides. Tetrahedron Lett. 1993, 34 (41), 6599-6602. doi: 10.1016/0040-4039(93)88115-y.