Fmoc-AA-TentaGel® S TRT resin

Fmoc protected amino acids linked to TentaGel® S TRT

TentaGel® resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted. The PEG spacer is attached to the matrix via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. As PEG is a "chameleon type" polymer with hydrophobic and hydrophilic properties, the graft copolymer shows modified physico chemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix). These graft copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of MW 3000 Da.

Literature

L 4, L 5, L 6, L 7, L 24, L 25, L 39; see also: General Information.

Residues which are sensitive to racemisation during esterification reactions like His and Cys can be attached to the resin without racemisation. Due to the bulkiness of the trityl group, diketopiperazine formation is suppressed which makes this linker ideal for peptides with C-terminal Pro. This resin is recommended for synthesis of standard peptides up to 40 residues in length.

The sensitivity towards TFA is comparable to the 2-CT linker. Cleavage can be achieved with 50% AcOH in CH₂Cl₂ to liberate protected peptides. For free peptides 95% TFA is afforded.

Literature

L 15

price: 73 $

SA1201

Fmoc Ala TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SA1202

Fmoc Arg(Pbf) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.16 - 0.25 mmol/g

price: 124 $

SA1203

Fmoc Arg(Pmc) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.16 - 0.25 mmol/g

price: 86 $

SA1204

Fmoc Asn(Trt) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1205

Fmoc Asp(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1206

Fmoc Cys(Trt) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1207

Fmoc Cys(Acm) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1208

Fmoc Cys(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 111 $

SA1209

Fmoc Cys(StBu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1210

Fmoc Gln(Trt) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1212

Fmoc Glu(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 73 $

SA1213

Fmoc Gly TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1214

Fmoc His(Trt) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 73 $

SA1215

Fmoc Ile TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 73 $

SA1216

Fmoc Leu TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1217

Fmoc Lys(Boc) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 73 $

SA1218

Fmoc Met TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1219

Fmoc Nle TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SA1220

Fmoc Orn(Boc) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 73 $

SA1221

Fmoc Phe TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 73 $

SA1222

Fmoc Pro TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1223

Fmoc Ser(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1224

Fmoc Thr(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 86 $

SA1226

Fmoc Tyr(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 73 $

SA1227

Fmoc Val TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 113 $

SA1228

Fmoc Trp(Boc) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

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