HypoGel® RAM Resins

This resin is functionalized with a modified Rink Amide linker and is ideal for the Fmoc SPPS of peptide amides. Cleavage from this support is achieved with 95% TFA to give peptide amides. This resin is recommended for the synthesis of short peptide amides (10 - 15 residues).

HypoGel® is a hydrophilic gel type resin which combines high capacities with good solvent compatibility. Glycol spacers with n = 5 or 10 EO units separate the reactive sites from the polystyrene matrix and modify the hydrophobic properties of the polystyrene backbone. Due to the spacer effect the functional group shows a higher mobility which results in higher kinetic rates and high resolution NMR spectra from immobilized compounds on the bead. The resin is compatible to a wide range of solvents and in contrast to polystyrene even polar solvents like methanol or ethanol can be used.

These resins show high loading and a hydrophilicity between polystyrene and TentaGel®

Literature

L 17

price: 224 $

SP200110150230

HypoGel® 200 RAM

n = 5
particle size: 110 - 150 µm
capacity: 0.5 - 0.7 mmol/g

price: 224 $

SP400110150230

HypoGel® 400 RAM

n = 10
particle size: 110 - 150 µm
capacity: 0.4 - 0.6 mmol/g

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