Fmoc-D-AA-TentaGel® S TRT resin

Fmoc protected amino acids linked to TentaGel® S TRT

TentaGel® resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted. The PEG spacer is attached to the matrix via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. As PEG is a "chameleon type" polymer with hydrophobic and hydrophilic properties, the graft copolymer shows modified physico chemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix). These graft copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of MW 3000 Da.

Literature

L 4, L 5, L 6, L 7, L 24, L 25, L 39; see also: General Information.

Residues which are sensitive to racemisation during esterification reactions like His and Cys can be attached to the resin without racemisation. Due to the bulkiness of the trityl group, diketopiperazine formation is suppressed which makes this linker ideal for peptides with C-terminal Pro. This resin is recommended for synthesis of standard peptides up to 40 residues in length.

The sensitivity towards TFA is comparable to the 2-CT linker. Cleavage can be achieved with 50% AcOH in CH₂Cl₂ to liberate protected peptides. For free peptides 95% TFA is afforded.

Literature

L 15

price: 104 $

SAD1201

Fmoc D-Ala TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1202

Fmoc D-Arg(Pbf) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.16 - 0.25 mmol/g

price: 124 $

SAD1203

Fmoc D-Arg(Pmc) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.16 - 0.25 mmol/g

price: 124 $

SAD1204

Fmoc D-Asn(Trt) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1205

Fmoc D-Asp(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1206

Fmoc D-Cys(Trt) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1207

Fmoc D-Cys(Acm) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1208

Fmoc D-Cys(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1209

Fmoc D-Cys(StBu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1210

Fmoc D-Gln(Trt) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1212

Fmoc D-Glu(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1214

Fmoc D-His(Trt) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 239 $

SAD1215

Fmoc D-Ile TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 104 $

SAD1216

Fmoc D-Leu TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1217

Fmoc D-Lys(Boc) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 104 $

SAD1218

Fmoc D-Met TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1219

Fmoc D-Nle TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 162 $

SAD1220

Fmoc D-Orn(Boc) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 104 $

SAD1221

Fmoc D-Phe TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 104 $

SAD1222

Fmoc D-Pro TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1223

Fmoc D-Ser(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1224

Fmoc D-Thr(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1226

Fmoc D-Tyr(t-Bu) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 104 $

SAD1227

Fmoc D-Val TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

price: 124 $

SAD1228

Fmoc D-Trp(Boc) TentaGel® S Trt resin

particle size: 90 µm
capacity: 0.18 - 0.25 mmol/g

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