ɑ-Methoxy-ω-Succinamic Acid NHS Ester PEGs
PEG-NHS derivatives are active esters and useful reagents to pegylate proteines, peptides or any other surfaces with a free primary amino group to form stable amide bonds. The Reaction requires a neutral to alkaline pH (7 to 8.5) to proceed. However, hydrolysis competes with aminolysis of the active ester and also increases with higher pH. Thus, working with excess PEG-NHS is necessary to obtain high pegylation yields. The amido succinic acid NHS derivative has a C3 amide linkage between PEG and the NHS Ester group. It is a comparably reactive PEG active ester with a hydrolysis half-life of a few minutes at pH 8.
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