ɑ-Methoxy-ω-Succinamic Acid NHS Ester PEG

ɑ-Methoxy-ω-NHS Ester PEG

€ 169,00*

SIZE

2000 Dalton

AMOUNT

Product number
122000-35.1G

Product information

PEG-NHS ester derivatives are active esters and useful reagents to pegylate proteines, peptides or any other surfaces with a free primary amino group to form stable amide bonds. The Reaction requires a neutral to alkaline pH (7 to 8.5) to proceed. However, hydrolysis competes with aminolysis of the active ester and also increases with higher pH. Thus, working with excess PEG-NHS is necessary to obtain high pegylation yields. The amido succinic acid NHS ester derivative has a C4 amide linkage between PEG and the NHS ester group. It is a comparably reactive PEG active ester with a hydrolysis half-life of a few minutes at pH 8.

Literature

L 67 α-Methoxy-ω-Amido Succinic Acid NHS Ester PEGs

Sahoo, K.; Karumuri, S.; Hikkaduwa Koralege, R. S.; Flynn, N. H.; Hartson, S.; Liu, J.; Ramsey, J. D.; Kalkan, A. K.; Pope, C.; Ranjan, A. Molecular and Biocompatibility Characterization of Red Blood Cell Membrane Targeted and Cell-Penetrating-Peptide-Modified Polymeric Nanoparticles. Mol. Pharm. 2017, 14 (7), 2224-2235. doi: 10.1021/acs.molpharmaceut.7b00053

Li, S.; Zhang, D.; Sheng, S.; Sun, H. Targeting Thyroid Cancer with Acid-Triggered Release of Doxorubicin from Silicon Dioxide Nanoparticles. Int. J. Nanomedicine 2017, 12, 5993-6003. doi: 10.2147/ijn.s137335

Rackley, L.; Stewart, J. M.; Salotti, J.; Krokhotin, A.; Shah, A.; Halman, J. R.; Juneja, R.; Smollett, J.; Lee, L.; Roark, K.; Viard, M.; Tarannum, M.; Vivero-Escoto, J.; Johnson, P. F.; Dobrovolskaia, M. A.; Dokholyan, N. V.; Franco, E.; Afonin, K. A. RNA Fibers as Optimized Nanoscaffolds for SiRNA Coordination and Reduced Immunological Recognition. Adv. Funct. Mater. 2018, 28 (48), 1805959. doi: 10.1002/adfm.201805959

Seaberg, J.; Flynn, N.; Cai, A.; Ramsey, J. D. Effect of Redox-Responsive DTSSP Crosslinking on Poly(l-Lysine)-Grafted-Poly(Ethylene Glycol) Nanoparticles for Delivery of Proteins. Biotechnol. Bioeng. 2020, 117 (8), 2504-2515. doi: 10.1002/bit.27369

Singh, M. P.; Flynn, N. H.; Sethuraman, S. N.; Manouchehri, S.; Ritchey, J.; Liu, J.; Ramsey, J. D.; Pope, C.; Ranjan, A. Reprogramming the Rapid Clearance of Thrombolytics by Nanoparticle Encapsulation and Anchoring to Circulating Red Blood Cells. J. Control. Release 2021, 329, 148-161. doi: 10.1016/j.jconrel.2020.11.034