ɑ-Methoxy-ω-Squaric Acid Ester Amido PEGs
Squaric Acid Ester Amido Methoxy-PEGs are a novel class of reactive and chemoselective PEGylation reagents. The squaric acid ester PEGs are chemoselective towards the amino groups of Lysin in protein PEGylation whereas the guanidine function of Arginine, the hydroxyl group of Serine and the imidazole function of Histidine are not affected. Compared to other active esters, these PEGs are remarkably stable in aqueous media and not easily hydrolyzed.
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