ɑ-Propargylacetamido-ω-Amino PEG

ɑ-Alkyne-ω-Amine PEG

Product information

PEGylation reagent for "Click" Chemistry. This PEG crosslinking reagent with a terminal alkyne functionality on one chain end reacts with azides under "Click" Chemistry conditions (for example Cu(I) catalyzed alkyne-azide cycloaddition, CuAAC) to form a stable triazole link between the two reaction partners. The amine functional group at one end of the PEG linker molecule allows for selective and covalent attachment to other molecules with complementary functional groups, such as carboxylic acids or activated esters, aldehydes and epoxides. The newly formed bonds are amides, imines or secondary amines. Applicable for reversible or permanent crosslinking with PEG.


Literature

L 106 α-Amino-ω-Alkyne PEGs

  1. Foy, J. T.; Li, Q.; Goujon, A.; Colard-Itté, J.-R.; Fuks, G.; Moulin, E.; Schiffmann, O.; Dattler, D.; Funeriu, D. P.; Giuseppone, N. Dual-Light Control of Nanomachines That Integrate Motor and Modulator Subunits. Nat. Nanotechnol. 2017, 12 (6), 540-545. doi: 10.1038/nnano.2017.28
  2. Collot, M.; Loukou, C.; Yakovlev, A. V.; Wilms, C. D.; Li, D.; Evrard, A.; Zamaleeva, A.; Bourdieu, L.; Léger, J.-F.; Ropert, N.; Eilers, J.; Oheim, M.; Feltz, A.; Mallet, J.-M. Calcium Rubies: A Family of Red-Emitting Functionalizable Indicators Suitable for Two-Photon Ca2+ Imaging. J. Am. Chem. Soc. 2012, 134 (36), 14923-14931. doi: 10.1021/ja304018d
  3. Scialabba, C.; Sciortino, A.; Messina, F.; Buscarino, G.; Cannas, M.; Roscigno, G.; Condorelli, G.; Cavallaro, G.; Giammona, G.; Mauro, N. Highly Homogeneous Biotinylated Carbon Nanodots: Red-Emitting Nanoheaters as Theranostic Agents toward Precision Cancer Medicine. ACS Appl. Mater. Interfaces 2019, 11 (22), 19854-19866. doi: 10.1021/acsami.9b04925
  4. Longo, J.; Yao, C.; Rios, C.; Chau, N. T. T.; Boulmedais, F.; Hemmerlé, J.; Lavalle, P.; Schiller, S. M.; Schaaf, P.; Jierry, L. Reversible Biomechano-Responsive Surface Based on Green Fluorescent Protein Genetically Modified with Unnatural Amino Acids. Chem. Commun. (Camb.) 2015, 51 (1), 232-235. doi: 10.1039/c4cc07486f
  5. Fan, J.; He, Q.; Wang, Z.; Huang, W.; Cai, Z. Self-Assembled Nanocomplex for Co-Delivery of Arsenic-Retinoic Acid Prodrug into Acute Promyelocytic Leukemia Cells. J. Biomed. Nanotechnol. 2018, 14 (6), 1052-1065. doi: 10.1166/jbn.2018.2556