Iodoacetyl PEG Derivatives
The iodoacetamide group is known for its ability to react selectively with cysteine residues in proteins or other thiols, forming stable covalent bonds via thioether linkage. This allows for the site-specific pegylation of proteins, enabling the attachment of various functional groups on the other chain end of the PEG linker. Iodoacetamide PEGs react with other nucleophiles to a significantly lesser degree.
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