ɑ-Mercapto-ω-Amino PEG Hydrochloride

ɑ-Thiol-ω-Amine PEG

€ 386,00*

SIZE

10 000 Dalton

AMOUNT

Product number
1310000-40-20.500MG

Product information

This linear PEG derivative has a sulfhydryl group (-SH) on one chain end. The free thiol groups react readily with maleimido or iodacetamido functionalities or transition metal surfaces like gold, silver etc. Reaction with other free thiols leads to S-S disulfide bonds which can be cleaved by reducing agents. PEG thiols may also be conjugated by thiol-ene chemistry. The amine functional group at one end of the PEG linker molecule allows for selective and covalent attachment to other molecules with complementary functional groups, such as carboxylic acids or activated esters, aldehydes and epoxides. The newly formed bonds are amides, imines or secondary amines. Applicable for reversible or permanent crosslinking with PEG.

Literature

L 91 α-Mercapto-ω-Amino PEGs

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Sykes, E. A.; Chen, J.; Zheng, G.; Chan, W. C. W. Investigating the Impact of Nanoparticle Size on Active and Passive Tumor Targeting Efficiency. ACS Nano 2014, 8 (6), 5696-5706. doi: 10.1021/nn500299p

Lee, J.-S.; Green, J. J.; Love, K. T.; Sunshine, J.; Langer, R.; Anderson, D. G. Gold, Poly(Beta-Amino Ester) Nanoparticles for Small Interfering RNA Delivery. Nano Lett. 2009, 9 (6), 2402-2406. doi: 10.1021/nl9009793

Gulbakan, B.; Yasun, E.; Shukoor, M. I.; Zhu, Z.; You, M.; Tan, X.; Sanchez, H.; Powell, D. H.; Dai, H.; Tan, W. A Dual Platform for Selective Analyte Enrichment and Ionization in Mass Spectrometry Using Aptamer-Conjugated Graphene Oxide. J. Am. Chem. Soc. 2010, 132 (49), 17408-17410. doi: 10.1021/ja109042w

Kim, Y.-H.; Jeon, J.; Hong, S. H.; Rhim, W.-K.; Lee, Y.-S.; Youn, H.; Chung, J.-K.; Lee, M. C.; Lee, D. S.; Kang, K. W.; Nam, J.-M. Tumor Targeting and Imaging Using Cyclic RGD-PEGylated Gold Nanoparticle Probes with Directly Conjugated Iodine-125. Small 2011, 7 (14), 2052-2060. doi: 10.1002/smll.201100927

Xia, X.; Yang, M.; Wang, Y.; Zheng, Y.; Li, Q.; Chen, J.; Xia, Y. Quantifying the Coverage Density of Poly(Ethylene Glycol) Chains on the Surface of Gold Nanostructures. ACS Nano 2012, 6 (1), 512-522. doi: 10.1021/nn2038516