ɑ-Hydroxy-ω-Tritylmercaptopropanamido PEG

ɑ-Hydroxy-ω-Tritylthio PEG

€ 236,00*

SIZE

10 000 Dalton

AMOUNT

Product number
1310000-00-41.500MG

Product information

The hydroxy group on one side of this PEG crosslinker is able to undergo esterification reactions with acids for reversible pegylation. It also enables further derivatization or replacement with other reactive functional groups. PEG tritylthio derivatives feature a protected thiol at on chain end. Trityl groups are easily removed with acid. Pure TFA or TFA/DCM mixtures cleave trityl from thiols quantitatively.

Literature

L 98 α-Hydroxy-ω-Tritylthio PEGs

Michelena, O.; Padro, D.; Carrillo-Carrión, C.; del Pino, P.; Blanco, J.; Arnaiz, B.; Parak, W. J.; Carril, M. Novel fluorinated ligands for gold nanoparticle labelling with applications in 19F-MRI. Chem. Commun. (Camb.) 2017, 53 (16), 2447-2450. doi: 10.1039/C6CC08900C

Glaser, M.; Karlsen, H.; Solbakken, M.; Arukwe, J.; Brady, F.; Luthra, S. K.; Cuthbertson, A. 18F-Fluorothiols: A New Approach to Label Peptides Chemoselectively as Potential Tracers for Positron Emission Tomography. Bioconjug. Chem. 2004, 15 (6), 1447-1453. doi: 10.1021/bc0498774

Luo, W.; Gobbo, P.; McNitt, C. D.; Sutton, D. A.; Popik, V. V.; Workentin, M. S. “Shine & Click” Photo-Induced Interfacial Unmasking of Strained Alkynes on Small Water-Soluble Gold Nanoparticles. Chemistry 2017, 23 (5), 1052-1059. doi: 10.1002/chem.201603398

Meuleman, T. J.; Dunlop, J. I.; Owsianka, A. M.; van de Langemheen, H.; Patel, A. H.; Liskamp, R. M. J. Immobilization by Surface Conjugation of Cyclic Peptides for Effective Mimicry of the HCV-Envelope E2 Protein as a Strategy toward Synthetic Vaccines. Bioconjug. Chem. 2018, 29 (4), 1091-1101. doi: 10.1021/acs.bioconjchem.7b00755

Ghiassian, S.; Yu, L.; Gobbo, P.; Nazemi, A.; Romagnoli, T.; Luo, W.; Luyt, L. G.; Workentin, M. S. Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as 18F-Labeled Positron Emission Tomography Probes via I-SPANC. ACS Omega 2019, 4 (21), 19106-19115. doi: 10.1021/acsomega.9b02322

Sasmal, R.; Das Saha, N.; Schueder, F.; Joshi, D.; Sheeba, V.; Jungmann, R.; Agasti, S. S. Dynamic Host-Guest Interaction Enables Autonomous Single Molecule Blinking and Super-Resolution Imaging. Chem. Commun. (Camb.) 2019, 55 (96), 14430-14433. doi: 10.1039/c9cc07153a