€ 296,00*
SIZE
10 000 Dalton
Product number
1310000-00-37.500MG
1310000-00-37.500MG
Product information
The hydroxy group on one side of this PEG crosslinker is able to undergo esterification reactions with acids for reversible pegylation. It also enables further derivatization or replacement with other reactive functional groups. The protected hydrazine may be liberated by treating the Boc group with acid. The hydrazine group is used to conjugate carbonyl compounds like aldehydes or ketones with the formation of hydrolysable and pH sensitive hydrazone links.
Literature
L 103 α-Hydroxy-ω-Hydrazido PEGs
- Gavrilyuk, J.; Ban, H.; Nagano, M.; Hakamata, W.; Barbas, C. F., 3rd. Formylbenzene Diazonium Hexafluorophosphate Reagent for Tyrosine-Selective Modification of Proteins and the Introduction of a Bioorthogonal Aldehyde. Bioconjug. Chem. 2012, 23 (12), 2321-2328. doi: 10.1021/bc300410p
- Wan, Q.; Zeng, G.; He, Z.; Mao, L.; Liu, M.; Huang, H.; Deng, F.; Zhang, X.; Wei, Y. Fabrication and Biomedical Applications of AIE Active Nanotheranostics through the Combination of a Ring-Opening Reaction and Formation of Dynamic Hydrazones. J. Mater. Chem. B Mater. Biol. Med. 2016, 4 (34), 5692-5699. doi: 10.1039/c6tb01452f
- Stephen, Z. R.; Gebhart, R. N.; Jeon, M.; Blair, A. A.; Ellenbogen, R. G.; Silber, J. R.; Zhang, M. PH-Sensitive O6-Benzylguanosine Polymer Modified Magnetic Nanoparticles for Treatment of Glioblastomas. Bioconjug. Chem. 2017, 28 (1), 194-202. doi: 10.1021/acs.bioconjchem.6b00545