€ 332,00*
SIZE
10 000 Dalton
Product number
1310000-00-5.500MG
1310000-00-5.500MG
Product information
This PEG crosslinking reagent with a terminal azide functionality at one chain end reacts with DBCO, BCN or other alkynes under "Click" Chemistry conditions (for example Cu(I) catalyzed alkyne-azide cycloaddition, CuAAC) to form a stable triazole link between the two reaction partners. The hydroxy group on one side of this PEG crosslinker is able to undergo esterification reactions with acids for reversible pegylation. It also enables further derivatization or replacement with other reactive functional groups.
Literature
L 56 “Click”-Chemistry
- Kolb, H. C.; Finn, M. G.; Sharpless, K. B. Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Angew. Chem. Int. Ed Engl. 2001, 40 (11), 2004-2021. doi: 10.1002/1521-3773(20010601)40:11<2004::aid-anie2004>3.3.co;2-x.
- Kolb, H. C.; Sharpless, K. B. The Growing Impact of Click Chemistry on Drug Discovery. Drug Discov. Today 2003, 8 (24), 1128-1137. doi: 10.1016/s1359-6446(03)02933-7.
- Bock, V. D.; Hiemstra, H.; van Maarseveen, J. H. Cu I ‐catalyzed Alkyne-Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective. European J. Org. Chem. 2006, 2006 (1), 51-68. doi: 10.1002/ejoc.200500483.
- Altintas, O.; Yankul, B.; Hizal, G.; Tunca, U. A3-Type Star Polymers via Click Chemistry. J. Polym. Sci. A Polym. Chem. 2006, 44 (21), 6458-6465. doi: 10.1002/pola.21728.
- Kantam, M. L.; Jaya, V. S.; Sreedhar, B.; Rao, M. M.; Choudary, B. M. Preparation of Alumina Supported Copper Nanoparticles and Their Application in the Synthesis of 1,2,3-Triazoles. J. Mol. Catal. A Chem. 2006, 256 (1-2), 273-277. doi: 10.1016/j.molcata.2006.04.054.
- Bonnet, D.; Ilien, B.; Galzi, J.-L.; Riché, S.; Antheaune, C.; Hibert, M. A Rapid and Versatile Method to Label Receptor Ligands Using “Click” Chemistry: Validation with the Muscarinic M1 Antagonist Pirenzepine. Bioconjug. Chem. 2006, 17 (6), 1618-1623. doi: 10.1021/bc060140j.