ɑ-Hydroxy-ω-Amino PEG

ɑ-Hydroxy-ω-Amine PEG

€ 182,00*

SIZE

10 000 Dalton

AMOUNT

Product number
1310000-00-20.500MG

Product information

The amine functional group at one end of the PEG linker molecule allows for selective and covalent attachment to other molecules with complementary functional groups, such as carboxylic acids or activated esters, aldehydes and epoxides. The newly formed bonds are amides, imines or secondary amines. Applicable for reversible or permanent crosslinking with PEG. The hydroxy group on one side of this PEG crosslinker is able to undergo esterification reactions with acids for reversible pegylation. It also enables further derivatization or replacement with other reactive functional groups.

Literature

L 105 α-Hydroxy-ω-Amino PEGs

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Prabaharan, M.; Grailer, J. J.; Pilla, S.; Steeber, D. A.; Gong, S. Amphiphilic Multi-Arm-Block Copolymer Conjugated with Doxorubicin via PH-Sensitive Hydrazone Bond for Tumor-Targeted Drug Delivery. Biomaterials 2009, 30 (29), 5757-5766. doi: 10.1016/j.biomaterials.2009.07.020

Ryman-Rasmussen, J. P.; Riviere, J. E.; Monteiro-Riviere, N. A. Penetration of Intact Skin by Quantum Dots with Diverse Physicochemical Properties. Toxicol. Sci. 2006, 91 (1), 159-165. doi: 10.1093/toxsci/kfj122

Johnson, J. A.; Lu, Y. Y.; Burts, A. O.; Lim, Y.-H.; Finn, M. G.; Koberstein, J. T.; Turro, N. J.; Tirrell, D. A.; Grubbs, R. H. Core-Clickable PEG-Branch-Azide Bivalent-Bottle-Brush Polymers by ROMP: Grafting-through and Clicking-To. J. Am. Chem. Soc. 2011, 133 (3), 559-566. doi: 10.1021/ja108441d

Xiao, Z.; Ji, C.; Shi, J.; Pridgen, E. M.; Frieder, J.; Wu, J.; Farokhzad, O. C. DNA Self-Assembly of Targeted near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy. Angew. Chem. Int. Ed Engl. 2012, 51 (47), 11853-11857. doi: 10.1002/anie.201204018

Sun, X.; Rossin, R.; Turner, J. L.; Becker, M. L.; Joralemon, M. J.; Welch, M. J.; Wooley, K. L. An Assessment of the Effects of Shell Cross-Linked Nanoparticle Size, Core Composition, and Surface PEGylation on in Vivo Biodistribution. Biomacromolecules 2005, 6 (5), 2541-2554. doi: 10.1021/bm050260e

Liu, Y.; Ai, K.; Ji, X.; Askhatova, D.; Du, R.; Lu, L.; Shi, J. Comprehensive Insights into the Multi-Antioxidative Mechanisms of Melanin Nanoparticles and Their Application to Protect Brain from Injury in Ischemic Stroke. J. Am. Chem. Soc. 2017, 139 (2), 856-862. doi: 10.1021/jacs.6b11013

Allen, P. M.; Liu, W.; Chauhan, V. P.; Lee, J.; Ting, A. Y.; Fukumura, D.; Jain, R. K.; Bawendi, M. G. InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the near-Infrared. J. Am. Chem. Soc. 2010, 132 (2), 470-471. doi: 10.1021/ja908250r