ɑ-Biotinamido-ω-Mercaptopropanamido PEG

ɑ-Biotin-ω-Thiol PEG

Product information

PEG crosslinking agents for biotinylation. The biotinyl functionality is used to attach avidin or streptavidin containing substrates. Pegylation by binding of biotinyl PEG to avidin and streptavidin is very specific and fast. This linear PEG derivative has a sulfhydryl group (-SH) on one chain end. The free thiol groups react readily with maleimido or iodacetamido functionalities or transition metal surfaces like gold, silver etc. Reaction with other free thiols leads to S-S disulfide bonds which can be cleaved by reducing agents. PEG thiols may also be conjugated by thiol-ene chemistry.


Literature

L 78 α-Biotinyl-ω-Mercapto PEGs

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  2. Wang, Y.; van Asdonk, K.; Zijlstra, P. A Robust and General Approach to Quantitatively Conjugate Enzymes to Plasmonic Nanoparticles. Langmuir 2019, 35 (41), 13356-13363.
  3. Gao, S.; Chen, S.; Lu, Q. Real-Time Profiling of Anti-(Epithelial Cell Adhesion Molecule)-Based Immune Capture from Molecules to Cells Using Multiparameter Surface Plasmon Resonance. Langmuir 2019, 35 (4), 1040-1046. doi: 10.1021/acs.langmuir.8b03898
  4. Misbah, I.; Zhao, F.; Shih, W.-C. Symmetry Breaking-Induced Plasmonic Mode Splitting in Coupled Gold-Silver Alloy Nanodisk Array for Ultrasensitive RGB Colorimetric Biosensing. ACS Appl. Mater. Interfaces 2019, 11 (2), 2273-2281. doi: 10.1021/acsami.8b17876
  5. Yang, Y.; Kannisto, E.; Yu, G.; Reid, M. E.; Patnaik, S. K.; Wu, Y. An Immuno-Biochip Selectively Captures Tumor-Derived Exosomes and Detects Exosomal RNAs for Cancer Diagnosis. ACS Appl. Mater. Interfaces 2018, 10 (50), 43375-43386. doi: 10.1021/acsami.8b13971
  6. Heo, D. N.; Yang, D. H.; Moon, H.-J.; Lee, J. B.; Bae, M. S.; Lee, S. C.; Lee, W. J.; Sun, I.-C.; Kwon, I. K. Gold Nanoparticles Surface-Functionalized with Paclitaxel Drug and Biotin Receptor as Theranostic Agents for Cancer Therapy. Biomaterials 2012, 33 (3), 856-866. doi: 10.1016/j.biomaterials.2011.09.064
  7. Zhang, P.; Chen, L.; Xu, T.; Liu, H.; Liu, X.; Meng, J.; Yang, G.; Jiang, L.; Wang, S. Programmable Fractal Nanostructured Interfaces for Specific Recognition and Electrochemical Release of Cancer Cells. Adv. Mater. 2013, 25 (26), 3566-3570. doi:: 10.1002/adma.201300888
  8. Jonsson, M. P.; Dahlin, A. B.; Feuz, L.; Petronis, S.; Höök, F. Locally Functionalized Short-Range Ordered Nanoplasmonic Pores for Bioanalytical Sensing. Anal. Chem. 2010, 82 (5), 2087-2094. doi: 10.1021/ac902925e
  9. Feuz, L.; Jonsson, M. P.; Höök, F. Material-Selective Surface Chemistry for Nanoplasmonic Sensors: Optimizing Sensitivity and Controlling Binding to Local Hot Spots. Nano Lett. 2012, 12 (2), 873-879. doi: 10.1021/nl203917e
  10. Li, J.; Zhu, Z.; Zhu, B.; Ma, Y.; Lin, B.; Liu, R.; Song, Y.; Lin, H.; Tu, S.; Yang, C. Surface-Enhanced Raman Scattering Active Plasmonic Nanoparticles with Ultrasmall Interior Nanogap for Multiplex Quantitative Detection and Cancer Cell Imaging. Anal. Chem. 2016, 88 (15), 7828-7836. doi: 10.1021/acs.analchem.6b01867