Magnetic Resins
Figure 1: Principle structure of a magnetic resin.
Purpose: protein purification, RNA and DNA extraction, immunoprecipitation but also in NGS and PCR application.
The novel magnetic beads are based on polystyrene beads where the magnetic core is imbedded into a low crosslinked polystyrene matrix. All properties known from traditional polystyrene resins used in solid phase organic synthesis (SPOS) like swelling and shrinking in organic solvents are still the same.
Several reaction types like amide couplings, nucleophilic aromatic substitution and Suzuki-Miyaura reactions were successfully performed in a parallel synthesis approach on micromole scale.
Available as Magnetic Polystyrene AM NH2.
Figure 2: Static and dynamik separation of magnetic from non-magnetic beads.
References
Mueller, S., Gosling, D., Palmieri, M., Goff, A.-L.L., Meyer, D. and Meier, P., Automation of Multistep Reaction-Based Solid-Phase Synthesis Using Novel Polystyrene-Coated Magnetic Particles. Chem. Eur. J., 31: e01429. 2025, doi: 10.1002/chem.202501429