HypoGel® 200 REM

€ 89,00*

SIZE

110 - 150 µm

Capacity

0.5 - 0.9 mmol/g

AMOUNT

Product number
SP200110150180.5G

Product information

HypoGel^® is a novel hydrophilic Gel^® type resin which combines high capacities with good solvent compatibility. Glycol spacers with n = 5 or 10 EO units separate the reactive sites from the polystyrene matrix and modify the hydrophobic properties of the polystyrene backbone. Due to the spacer effect the functional group shows a higher mobility which results in higher kinetic rates and high resolution NMR spectra from immobilized compounds on the bead. The resin is compatible to a wide range of solvents and in contrast to polystyrene even polar solvents like methanol or ethanol can be used. These resins show high loading and a hydrophilicity between polystyrene and TentaGel^®.
REM resin for a broad range of solvents.
This resin with the immobilized acrylic acid is a support for the SOPS of tertiary amines. The first step is a Michael addition of a primary or secondary amine followed by quarternization with the appropriate alkyl halide. β-Elimination yields the tertiary amine.
In this resin the glycol spacer contains 5 EO units which separate the reactive sites from the polystyrene matrix.

Literature

L 17 HypoGel^®

Rapp W., Recent Advances in Synthesis and Use of High Load Spacer-modified Supports in SPS in Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries, Collected Papers of the 7th International Symposium 2001 (Epton, R., Ed.); Mayflower Wordwide: Kingswinford, England, 2002, 9.

L 43 REM Resins

Brown, A. R.; Rees, D. C.; Rankovic, Z.; Morphy, J. R. Synthesis of Tertiary Amines Using a Polystyrene (REM) Resin. J. Am. Chem. Soc. 1997, 119 (14), 3288-3295. doi: 10.1021/ja963829f.

Bom, A.; Booth, S.; Bruin, J.; Clark, J.; Miller, S.; Wathey, B. Parallel Solid-Phase Synthesis of Zatebradine Analogues as Potential If Channel Blockers. Bioorg. Med. Chem. Lett. 2001, 11 (17), 2351-2354. doi: 10.1016/s0960-894x(01)00424-3.

Cottney, J.; Rankovic, Z.; Morphy, J. R. Synthesis of Novel Analogues of the Delta Opioid Ligand SNC-80 Using REM Resin. Bioorg. Med. Chem. Lett. 1999, 9 (9), 1323-1328. doi: 10.1016/s0960-894x(99)00173-0.