€ 121,00*
SIZE
2000 Dalton
Product number
122000-70.500MG
122000-70.500MG
Product information
PEGylation reagent for "Click" Chemistry. This PEG reagent with a terminal alkyne functionality reacts with azides under "Click" Chemistry conditions (for example Cu(I) catalyzed alkyne-azide cycloaddition, CuAAC) to form a stable triazole link between the two reaction partners.
Literature
L 56 “Click”-Chemistry
- Kolb, H. C.; Finn, M. G.; Sharpless, K. B. Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Angew. Chem. Int. Ed Engl. 2001, 40 (11), 2004-2021. doi: 10.1002/1521-3773(20010601)40:11<2004::aid-anie2004>3.3.co;2-x.
- Kolb, H. C.; Sharpless, K. B. The Growing Impact of Click Chemistry on Drug Discovery. Drug Discov. Today 2003, 8 (24), 1128-1137. doi: 10.1016/s1359-6446(03)02933-7.
- Bock, V. D.; Hiemstra, H.; van Maarseveen, J. H. Cu I ‐catalyzed Alkyne-Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective. European J. Org. Chem. 2006, 2006 (1), 51-68. doi: 10.1002/ejoc.200500483.
- Altintas, O.; Yankul, B.; Hizal, G.; Tunca, U. A3-Type Star Polymers via Click Chemistry. J. Polym. Sci. A Polym. Chem. 2006, 44 (21), 6458-6465. doi: 10.1002/pola.21728.
- Kantam, M. L.; Jaya, V. S.; Sreedhar, B.; Rao, M. M.; Choudary, B. M. Preparation of Alumina Supported Copper Nanoparticles and Their Application in the Synthesis of 1,2,3-Triazoles. J. Mol. Catal. A Chem. 2006, 256 (1-2), 273-277. doi: 10.1016/j.molcata.2006.04.054.
- Bonnet, D.; Ilien, B.; Galzi, J.-L.; Riché, S.; Antheaune, C.; Hibert, M. A Rapid and Versatile Method to Label Receptor Ligands Using “Click” Chemistry: Validation with the Muscarinic M1 Antagonist Pirenzepine. Bioconjug. Chem. 2006, 17 (6), 1618-1623. doi: 10.1021/bc060140j.