€ 185,00*
SIZE
2000 Dalton
Product number
122000-45.1G
122000-45.1G
Product information
This linear PEG derivative is applied in sulfhydryl-selective coupling of PEG to proteins and other thiol substrates and for selective scavenging of thiol containing peptides. The maleimide group reacts at about neutral pH with free thiols via a Michael addition to form a stable thioether bond.
Literature
L 70 α-Methoxy-ω-Maleinimido PEGs
- Inada, H.; Procko, E.; Sotomayor, M.; Gaudet, R. Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel. Biochemistry 2012, 51 (31), 6195-6206. doi: 10.1021/bi300279b.
- Dengler, M. A.; Robin, A. Y.; Gibson, L.; Li, M. X.; Sandow, J. J.; Iyer, S.; Webb, A. I.; Westphal, D.; Dewson, G.; Adams, J. M. BAX Activation: Mutations near Its Proposed Non-Canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association. Cell Rep. 2019, 27 (2), 359-373.e6. doi: 10.1016/j.celrep.2019.03.040.
- Cioloboc, D.; Kennedy, C.; Boice, E. N.; Clark, E. R.; Kurtz, D. M., Jr. Trojan Horse for Light-Triggered Bifurcated Production of Singlet Oxygen and Fenton-Reactive Iron within Cancer Cells. Biomacromolecules 2018, 19 (1), 178-187. doi: 10.1021/acs.biomac.7b01433.
- Delgado, J. D.; Surmaitis, R. L.; Abou Shaheen, S.; Schlenoff, J. B. Engineering Thiolated Surfaces with Polyelectrolyte Multilayers. ACS Appl. Mater. Interfaces 2019, 11 (3), 3524-3535. doi: 10.1021/acsami.8b15514.
- Li, M. X.; Tan, I. K. L.; Ma, S. B.; Hockings, C.; Kratina, T.; Dengler, M. A.; Alsop, A. E.; Kluck, R. M.; Dewson, G. BAK α6 Permits Activation by BH3-Only Proteins and Homooligomerization via the Canonical Hydrophobic Groove. Proc. Natl. Acad. Sci. U. S. A. 2017, 114 (29), 7629-7634. doi: 10.1073/pnas.1702453114.
- Procko, E.; Berguig, G. Y.; Shen, B. W.; Song, Y.; Frayo, S.; Convertine, A. J.; Margineantu, D.; Booth, G.; Correia, B. E.; Cheng, Y.; Schief, W. R.; Hockenbery, D. M.; Press, O. W.; Stoddard, B. L.; Stayton, P. S.; Baker, D. A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells. Cell 2014, 157 (7), 1644-1656. doi: 10.1016/j.cell.2014.04.034.
- Pang, T.; Savva, C. G.; Fleming, K. G.; Struck, D. K.; Young, R. Structure of the Lethal Phage Pinhole. Proc. Natl. Acad. Sci. U. S. A. 2009, 106 (45), 18966-18971. doi: 10.1073/pnas.0907941106.
- Devaraneni, P. K.; Devereaux, J. J.; Valiyaveetil, F. I. In Vitro Folding of KvAP, a Voltage-Gated K+ Channel. Biochemistry 2011, 50 (48), 10442-10450. doi: 10.1021/bi2012965.
- Savva, C. G.; Dewey, J. S.; Deaton, J.; White, R. L.; Struck, D. K.; Holzenburg, A.; Young, R. The Holin of Bacteriophage Lambda Forms Rings with Large Diameter. Mol. Microbiol. 2008, 69 (4), 784-793. doi: 10.1111/j.1365-2958.2008.06298.x.