€ 244,00*
SIZE
10 000 Dalton
Product number
1210000-6.1G
1210000-6.1G
Product information
PEG aldehydes are mostly amine reactive pegylation reagents. They react with free amines, peptides and proteins forming an imine bond, which can be reduced afterwards or insitu by hydrides to form a stable secondary amine bond. However, with hydrazide substrates, hydrolytically unstable hydrazone bonds are formed, thus making reversible pegylation possible.
Literature
L 72 α-Methoxy-ω-Formyl PEG
- Zaghmi, A.; Mendez-Villuendas, E.; Greschner, A. A.; Liu, J. Y.; de Haan, H. W.; Gauthier, M. A. Mechanisms of Activity Loss for a Multi-PEGylated Protein by Experiment and Simulation. Mater. Today Chem. 2019, 12, 121-131. doi: 10.1016/j.mtchem.2018.12.007.
- Dilla, R. A.; Motta, C. M. M.; Xu, Y.; Zander, Z. K.; Bernard, N.; Wiener, C. G.; Vogt, B. D.; Becker, M. L. Mechanically Tunable, Human Mesenchymal Stem Cell Viable Poly(Ethylene Glycol)-Oxime Hydrogels with Invariant Precursor Composition, Concentration, and Stoichiometry. Mater. Today Chem. 2019, 11, 244-252. doi: 10.1016/j.mtchem.2018.11.003.