€ 242,00*
free NH2 capacity: 2 - 8 µmmol/g
B30132.12.1G
Product information
TentaGel® resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. The graft copolymer shows modified physicochemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix) and has hydrophobic and hydrophilic properties. These copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of MW 3000 Da. TentaGel® resins have high diffusion rates and excellent swelling in a wide range of solvents from e.g. toluene to water.
On this type of surface modified bifunctional TentaGel® resins the amino functions located inside the beads are Boc protected whereas the amino functions on the surface are free.
Literature
L 13 Multifunctional Resins
- Bayer, E. Towards the Chemical Synthesis of Proteins. Angew. Chem. Int. Ed. Engl. 1991, 30 (2), 113-129. doi: 10.1002/anie.199101133.
- Rapp W., Maier M., Schlotterbeck G., Pursch M., Albert K., Bayer E. Miniaturization in Chemistry: Macrobeads of 600 µm Diameter as Microreactors for Chemical Screening, Peptide Libraries and Combinatorial Chemistry in Peptides: Chemistry, Structure and Biology, Proceedings of the 14th American Peptide Symposium; (Kaumaya, P. T. P., Hodges, R. S., Eds.); Intercept: Wimborne, UK, 1996, 313.
- Rapp W., Nicholson G., Maier M., Schlotterbeck G., Pursch M., Albert K. Miniaturization in Chemistry: Chemical Possibilities and Physicochemical Properties of Polymeric Microreactors in Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries: Proceedings of the 4th International Symposium on Solid Phase Synthesis; (Epton, R., Ed.); Intercept: Wimborne, UK, 1996, 97-100.