€ 104,00*
SIZE
250 - 315 µm
Capacity
0.5 - 1.0 mmol/g
Product number
HA25031518.5G
HA25031518.5G
Product information
This resin with the immobilized acrylic acid is a support for the SOPS of tertiary amines. The first step is a Michael addition of a primary or secondary amine followed by quarternization with the appropriate alkyl halide. β-Elimination yields the tertiary amine.
Literature
L 43 REM Resins
- Brown, A. R.; Rees, D. C.; Rankovic, Z.; Morphy, J. R. Synthesis of Tertiary Amines Using a Polystyrene (REM) Resin. J. Am. Chem. Soc. 1997, 119 (14), 3288-3295. doi: 10.1021/ja963829f.
- Bom, A.; Booth, S.; Bruin, J.; Clark, J.; Miller, S.; Wathey, B. Parallel Solid-Phase Synthesis of Zatebradine Analogues as Potential If Channel Blockers. Bioorg. Med. Chem. Lett. 2001, 11 (17), 2351-2354. doi: 10.1016/s0960-894x(01)00424-3.
- Cottney, J.; Rankovic, Z.; Morphy, J. R. Synthesis of Novel Analogues of the Delta Opioid Ligand SNC-80 Using REM Resin. Bioorg. Med. Chem. Lett. 1999, 9 (9), 1323-1328. doi: 10.1016/s0960-894x(99)00173-0.