€ 167,00*
SP200110150140.5G
Product information
HypoGel® is a hydrophilic Gel® type resin which combines high capacities with good solvent compatibility. Glycol spacers with n = 5 (HypoGel® 200) or 10 (HypoGel® 400) EO units separate the reactive sites from the polystyrene matrix and modify the hydrophobic properties of the polystyrene backbone. Due to the spacer effect the functional group shows a higher mobility which results in higher kinetic rates and high resolution NMR spectra from immobilized compounds on the bead. The resin is compatible to a wide range of solvents and in contrast to polystyrene even polar solvents like methanol or ethanol can be used. These resins show high loading and a hydrophilicity between polystyrene and TentaGel®.
This resin is derived from HypoGel® amine and the base labile 4-(hydroxymethyl)benzoic acid linker. It is a versatile support for the immobilization of carboxylic acids.
The resulting ester bond is stable to strong acids but is cleaved by nucleophiles like amines, hydrazine or alkoxides to give amides, hydrazides or esters.
In this resin the glycol spacer contains 5 EO units which separate the reactive sites from the polystyrene matrix.
Literature
L 17 HypoGel®
- Rapp W., Recent Advances in Synthesis and Use of High Load Spacer-modified Supports in SPS in Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries, Collected Papers of the 7th International Symposium 2001 (Epton, R., Ed.); Mayflower Wordwide: Kingswinford, England, 2002, 9.
L 40 HMBA Linker
- Sheppard, R. C.; Williams, B. J. Acid-Labile Resin Linkage Agents for Use in Solid Phase Peptide Synthesis. Int. J. Pept. Protein Res. 1982, 20 (5), 451-454. doi: 10.1111/j.1399-3011.1982.tb03067.x.
- Atherton E., Sheppard R. C. in Solid Phase Peptide Synthesis: A Practical Approach; Atherton, E., Sheppard, R. A., Eds.; Oxford University Press: London, England, 1989, 152.
- Stewart J. M., Young J. D., in Solid Phase Peptide Synthesis, 2nd Ed., Rockford, Illinois, Pierce Chemical Company, 1984, 91.