€ 145,00*
H0370753301.5G
Product information
Amino acids linked to Polystyrene-2-chlorotrityl chloride resin.
A very acid sensitive resin suitable for the synthesis of protected peptide fragments by the Fmoc strategy. Residues which are sensitive to racemisation during esterification reactions like His and Cys can be attached to the resin without racemisation. Due to the bulkiness of the trityl group, diketopiperazine formation is suppressed which makes this linker ideal for peptides with C-terminal Pro. This resin has also been used in the solid phase synthesis of ß-peptides via the Arndt-Eistert homologation of Fmoc-protected amino acid diazoketones.
Cleavage from this resin is achieved for protected peptides by treatment either with AcOH/trifluoroethanol/DCM or 0.5% TFA in DCM or hexafluoroisopropanol. Free peptides are released with 95% TFA.
Fmoc D-amino acids on request
Literature
L 38 Polystyrene-2-Cl-Trt AA Resins
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- Barlos, K.; Gatos, D.; Papaphotiou, G.; Schäfer, W. Synthese von Calcitonin-Derivaten durch Fragmentkondensation in Lösung und am 2-Chlortrityl-Harz. Liebigs Ann. Chem. 1993, 1993 (3), 215-220. doi: 10.1002/jlac.199319930139.
- Barlos, K., Chatzi, O., Gatos, D., Stavropoulos, G. 2-Chlorotrityl chloride resin, Studies on anchoring of Fmoc-amino acids and peptide cleavage. Int. J. Peptide Protein Res. 1991, 37 (6), 513-520. doi: 10.1111/j.1399-3011.1991.tb00769.x
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- Barlos, K.; Gatos, D.; Kapolos, S.; Poulos, C.; Schäfer, W.; Yao, W. Q. Application of 2-Chlorotrityl Resin in Solid Phase Synthesis of (Leu15)-Gastrin I and Unsulfated Cholecystokinin Octapeptide. Selective O-Deprotection of Tyrosine. Int. J. Pept. Protein Res. 1991, 38 (6), 555-561. doi: 10.1111/j.1399-3011.1991.tb01539.x.
L 37 Chloro-(2’-chloro)trityl Polystyrene Resins
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- Barlos, K.; Gatos, D.; Kapolos, S.; Papaphotiu, G.; Schäfer, W.; Wenqing, Y. Veresterung von partiell geschützten Peptidfragmenten mit Harzen. Einsatz von 2-Chlortritylchlorid zur Synthese von Leu15 -gastrin I. Tetrahedron Lett. 1989, 30 (30), 3947-3950. doi: 10.1016/s0040-4039(00)99291-8.
- Barlos, K.; Gatos, D.; Schäfer, W. Synthesis of Prothymosinα(ProTα)—a Protein Consisting of 109 Amino Acid Residues. Angew. Chem. Int. Ed. Engl. 1991, 30 (5), 590-593. doi: 10.1002/anie.199105901.
- Barlos, K., Chatzi, O., Gatos, D., Stavropoulos, G. 2-Chlorotrityl chloride resin, Studies on anchoring of Fmoc-amino acids and peptide cleavage. Int. J. Peptide Protein Res. 1991, 37 (6), 513-520. doi: 10.1111/j.1399-3011.1991.tb00769.x
- Barlos, K.; Gatos, D.; Kutsogianni, S.; Papaphotiou, G.; Poulos, C.; Tsegenidis, T. Solid Phase Synthesis of Partially Protected and Free Peptides Containing Disulphide Bonds by Simultaneous Cysteine Oxidation-Release from 2-Chlorotrityl Resin. Int. J. Pept. Protein Res. 1991, 38 (6), 562-568. doi: 10.1111/j.1399-3011.1991.tb01540.x.
- Barlos, K.; Gatos, D.; Kapolos, S.; Poulos, C.; Schäfer, W.; Yao, W. Q. Application of 2-Chlorotrityl Resin in Solid Phase Synthesis of (Leu15)-Gastrin I and Unsulfated Cholecystokinin Octapeptide. Selective O-Deprotection of Tyrosine. Int. J. Pept. Protein Res. 1991, 38 (6), 555-561. doi: 10.1111/j.1399-3011.1991.tb01539.x.
- Barlos, K.; Gatos, D.; Papaphotiou, G.; Schäfer, W. Synthese von Calcitonin-Derivaten durch Fragmentkondensation in Lösung und am 2-Chlortrityl-Harz. Liebigs Ann. Chem. 1993, 1993 (3), 215-220. doi: 10.1002/jlac.199319930139.
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L 26 Polystyrene Resins
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L 24 Library Overview
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L 25 Libraries
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- Vágner J., Krchñák V., Sepetov N. F., Strop P., Lam K. S., Barany G., Lebl M. Novel Methodology for Differentiation of "Surface" and "Interior" Areas of Polyoxyethylene-Polystyrene (POE-PS) Supports: Application to Library Screening Procedures in Innovation and Perspectives in Solid Phase Synthesis and Related Technologies, Collected Papers, Third Int. Symp. Oxford, England, (Epton R., Ed.), 1994, 347-352.
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- Youngquist, R. S.; Fuentes, G. R.; Lacey, M. P.; Keough, T. Generation and Screening of Combinatorial Peptide Libraries Designed for Rapid Sequencing by Mass Spectrometry. J. Am. Chem. Soc. 1995, 117 (14), 3900-3906. doi: 10.1021/ja00119a002.
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