Polystyrene AM HMBA

Product information

This resin is derived from aminomethyl polystyrene and the base labile 4-(hydroxymethyl)benzoic acid linker. It is a versatile support for the immobilization of carboxylic acids.
The resulting ester bond is stable to strong acids but is cleaved by nucleophiles like amines, hydrazine or alkoxides to give amides, hydrazides or esters.


L 40 HMBA Linker

  1. Sheppard, R. C.; Williams, B. J. Acid-Labile Resin Linkage Agents for Use in Solid Phase Peptide Synthesis. Int. J. Pept. Protein Res. 1982, 20 (5), 451-454. doi: 10.1111/j.1399-3011.1982.tb03067.x.
  2. Atherton E., Sheppard R. C. in Solid Phase Peptide Synthesis: A Practical Approach; Atherton, E., Sheppard, R. A., Eds.; Oxford University Press: London, England, 1989, 152.
  3. Stewart J. M., Young J. D., in Solid Phase Peptide Synthesis, 2nd Ed., Rockford, Illinois, Pierce Chemical Company, 1984, 91.