HypoGel® 200 SH

€ 43,00*

SIZE

110 - 150 µm

Capacity

0.5 - 0.9 mmol/g

AMOUNT

Product number
SP20011015004.0.1G

Product information

HypoGel^® is a hydrophilic Gel^® type resin which combines high capacities with good solvent compatibility. Glycol spacers with n = 5 or 10 EO units separate the reactive sites from the polystyrene matrix and modify the hydrophobic properties of the polystyrene backbone. Due to the spacer effect the functional group shows a higher mobility which results in higher kinetic rates and high resolution NMR spectra from immobilized compounds on the bead. The resin is compatible to a wide range of solvents and in contrast to polystyrene even polar solvents like methanol or ethanol can be used. These resins show high loading and a hydrophilicity between polystyrene and TentaGel^®.
In this resin the glycol spacer contains 5 EO units which separate the reactive sites from the polystyrene matrix.

Literature

L 18 Immunization Overview

Modrow, S.; Höflacher, B.; Mertz, R.; Wolf, H. Carrier-Bound Synthetic Peptides. J. Immunol. Methods 1989, 118 (1), 1-7. doi: 10.1016/0022-1759(89)90045-8.

Fischer, P. M.; Comis, A.; Howden, M. E. H. Direct Immunization with Synthetic Peptidyl-Polyamide Resin. J. Immunol. Methods 1989, 118 (1), 119-123. doi: 10.1016/0022-1759(89)90061-6.

Flegel M., Pichova D., Minarik P., Sheppard R. C. Analogues of Gn-RH stimulating the enhanced production of antibodies. Synthesis and some biological effects of peptides containing adjuvant, lysine-branched, and solubilised polymer support components in Peptides 1990, Proceedings of the 21st European Peptide Symposium (Giralt E., Andreu D., Eds.), ESCOM, Leiden, 1991, 837.

Kanda, P.; Kennedy, R. C.; Sparrow, J. T. Synthesis of Polyamide Supports for Use in Peptide Synthesis and as Peptide-Resin Conjugates for Antibody Production. Int. J. Pept. Protein Res. 1991, 38 (4), 385-391. doi: 10.1111/j.1399-3011.1991.tb01518.x.

Kennedy, R. C.; Dreesman, G. R.; Chanh, T. C.; Boswell, R. N.; Allan, J. S.; Lee, T. H.; Essex, M.; Sparrow, J. T.; Ho, D. D.; Kanda, P. Use of a Resin-Bound Synthetic Peptide for Identifying a Neutralizing Antigenic Determinant Associated with the Human Immunodeficiency Virus Envelope. J. Biol. Chem. 1987, 262 (12), 5769-5774. doi: 10.1016/s0021-9258(18)45641-4.

Zeppezauer, M.; Hoffmann, R.; Schönberger, A.; Rawer, S.; Rapp, W.; Bayer, E. Hydrophilic Polystyrene-Polyoxyethylene Graft Polymer Beads as Carrier of Antigenic Peptides for in Vivo and in Vitro Immunization Techniques: Applications to the Non-Catalytic Zinc Loop of HLADH Isozymes and to Histone Fragments. Z. Naturforsch. B J. Chem. Sci. 1993, 48 (12), 1801-1806. doi: 10.1515/znb-1993-1217.

Rapp W., Zhang L., Beck-Sickinger A. G., Dares K., Wiesmüller K.-H., Jung G., Bayer E. Comparative study of antibody titers induced by a peptide epitope conjugated with protein, lipopeptide, polyoxyethylene and polyoxyethylene-polystyrene graft copolymer in Peptides 1990, Proceedings of the 21st European Peptide Symposium (Giralt E., Andreu D., Eds.) ESCOM, Leiden, 1991, 849.

Butz S., Rawer S., Rapp W., Birsner U., Immunization and affinity purification of antibodies using resin-immobilized lysine-branched synthetic peptides, Pept. Res., 1994, 7 (1), 20-23.