Aminomethylated polystyrene resins are prepared in-house from crosslinked polystyrenes by a direct aminomethylation reaction according to highly optimized protocols. Resins produced by our process are chemically defined, homogeneous and free from any additional crosslinking from the functionalization process. Aminomethylated polystyrene resins can easily be acylated with any appropriate carboxylic acid-containing linker using standard methods of amide bond formation to furnish supports for solid phase organic synthesis.

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