TentaGel® resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted. The PEG spacer is attached to the matrix via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. As PEG is a „chameleon type“ polymer with hydrophobic and hydrophilic properties, the graft copolymer shows modified physico chemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix). These graft copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of MW 3000 Da.
Due to the lack of amide bonds and of benzylic linkages as well as the excellent swelling properties in a great variety of solvents this resin is ideal for solid phase syntheses of secondary sulfonamides and carboxamides.

L 4, L 5, L 6, L 7, L 24, L 25, L 31; see also: General Information